Intracoronary Autologous CD34+ Stem Cell Therapy for Intractable Angina
نویسندگان
چکیده
منابع مشابه
Intracoronary autologous CD34+ stem cell therapy for intractable angina.
BACKGROUND/OBJECTIVES A large number of patients with coronary artery disease experience angina that is not suitable for revascularization and is refractory to conventional medical therapy. Laboratory and preclinical studies have provided evidence for the safety and potential efficacy of autologous CD34+ stem cell therapies as treatment for angina. Clinical studies investigating intramyocardial...
متن کاملIntramyocardial, autologous CD34+ cell therapy for refractory angina.
RATIONALE A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can improve myocardial perfusion and function. OBJECTIVE Evaluate the safety and bioactivity of intramyocardial injections of autologous CD34+ cells in patients with refractory angina who have exhausted ...
متن کاملCD34+ autologous human stem cells in treating refractory angina.
The article by Losordo et al1 in this issue of Circulation Research is an important addition to the relatively small body of literature in clinical cardiac stem cell therapy. Although the number of patients in the trial by Losordo et al is fairly small, only a handful of similarly sized trials have been published.2–4 In the recent past, the merit of performing clinical trials of cardiac cell th...
متن کاملIntramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial.
BACKGROUND A growing population of patients with coronary artery disease experiences angina that is not amenable to revascularization and is refractory to medical therapy. Preclinical studies have indicated that human CD34+ stem cells induce neovascularization in ischemic myocardium, which enhances perfusion and function. METHODS AND RESULTS Twenty-four patients (19 men and 5 women aged 48 to...
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Introduction: We aimed at evaluating the clinical, laboratory and echocardiography effects of intracoronary administration of autologous bone marrow stem cell transplantation in different clinical entities of chronic Heart Failure (HF) patients. Methods: This procedure was carried out during an interventional study conducted in the Cardiology department from JAN 2012 to APR 2013. The HF ...
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ژورنال
عنوان ژورنال: Cardiology
سال: 2010
ISSN: 1421-9751,0008-6312
DOI: 10.1159/000320217